Recapitulating our results in yeast, several c9orf72 ALS patient-derived fibroblasts and induced pluripotentstem cell (iPSCs) lines display similar increases in H3S10ph levels.Altogether, these findings reveal a previously undiscovered connectionbetween H3S10ph and c9 ALS/FTD proteinopathy that could reveal noveltargets for the treatment of this disease. The gene discussed is C9orf72; the disease is frontotemporal dementia.