Several neurodegenerative disease models have shown evidence thatthe presence of protein aggregates is associated with defects in nucleocytoplasmictransport., A Drosophila model recapitulatingthe generation of toxic RNA products and DPRs from the c9orf72 HRE found deficits in the nuclear pore complex in fly salivary glands. This leaves an open possibility of (PR)50 overexpression leading to similar deficiencies in the yeastmodel studied here. The gene discussed is C9orf72; the disease is neurodegenerative disease.