C9orf72 and amyotrophic lateral sclerosis: Fibroblasts have been used as model systems for ALS/FTDand are easy to grow in large numbers., Interestingly,some fibroblast lines recapitulated H3 methylation patterns foundin c9orf72 brains. Inthis study, we find a 25% increase in the levels of H3S10ph in fibroblastsderived from patients bearing c9orf72 repeat expansionscompared to age/sex-matched controls (Figure ).