Xu andco-workers used the Ugi-4CR reaction as a key step to obtaincompounds designed to promote ferroptosis by increasing the lipidperoxides in tumor cells leading to glutathione peroxidase 4 (GPX4)inhibition. The study employed the scaffoldhopping strategy to investigate structural modifications on the leadferroptosis regulator compound 61. This evidence concerns the gene GPX4 and neoplasm.