BCHE and Cognitive impairment: One of the most relevant hypothesesproposed to explain the cognitive impairment caused by this diseaseis the cholinergic hypothesis, which postulates that loss of cholinergicneurons is one of its causes and that the subsequent reduction ofacetylcholine levels in the synaptic cleft can be compensated throughthe inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase(BuChE).