For each 50 mg/dL increase in Lp(a), the risk of premature ASCVD increased by 30 % (HR: 1.30, 95% CI: 1.28–1.51), compared to a 24 % increase for non-premature ASCVD (HR: 1.24 [1.14–1.33]). The gene discussed is LPA; the disease is atherosclerosis.