A 50 mg/dL increase in Lp(a) was significantly associated with a 30 % higher risk of premature ASCVD (HR: 1.30[1.28–1.51, p = 0.0004]) and a 24 % higher risk of non-premature ASCVD (HR: 1.24 [1.14–1.33], p < 0.0001). Here, LPA is linked to atherosclerosis.