Additionally, there are emerging biomarkers for the prediction of risk for incident HF, including those reflecting cardio-renal interactions such as insulin-like growth factor binding protein or apoptosis/fibrosis markers, such as growth differentiation factor-15, the macrophage-based fibrosis biomarker galectin-3, and the interleukin receptor family member, ST2. The gene discussed is LGALS3; the disease is hydrops fetalis.