However, if a definitive cause for diabetic ketoacidosis is identified (e.g., low-calorie diet, postoperative catabolic state, and inappropriate cessation of insulin) reinstatement of SGLT-2 inhibitor may be considered depending on careful assessment of the individualized risks and benefits by a diabetes specialist (expert opinion, no high-grade evidence). The gene discussed is SLC5A2; the disease is diabetic ketoacidosis.