This drug is also used in ADHD (Faraone et al., 2015), which could elevate synaptic concentrations of dopamine and noradrenaline by inhibiting the reuptake of presynaptic dopamine transporter (DAT) and noradrenaline transporter, particularly in the striatum and frontal cortex (Salatino-Oliveira et al., 2011; Madras et al., 2005; Moreau et al., 2012). The gene discussed is SLC6A3; the disease is attention deficit-hyperactivity disorder.