In recent years, pathogenic variants in the DEPDC5 gene have been linked to a broad spectrum of epilepsy phenotypes, ranging from mild conditions such as febrile seizures and febrile seizure plus to severe developmental epileptic encephalopathies like West syndrome (Baldassari et al., 2019; Samanta, 2022). The gene discussed is DEPDC5; the disease is infantile spasms.