We extracted data from GTEx cortex and TCGA-GBM databases and discovered that several Wnt proteins, including WNT3A, WNT4, WNT5A, WNT6, WNT7A, and WNT9A, were up-regulated in GBM compared with the normal cerebral cortex (Fig. 1A, up panel). This evidence concerns the gene WNT6 and glioblastoma.