Additionally, the Wnt target genes AXIN2, MYC, LEF1, CCND1, ID2, VEGFA, RUNX2, PLAUR, JAG1, POU5F1, IRS1, TGFB3, and ABCG2 also exhibited increased expression in GBM as compared with the normal cerebral cortex (Fig. 1A, bottom panel). This evidence concerns the gene IRS1 and glioblastoma.