Microtubule associated monooxygenase, calponin and LIM domain containing 2 (MICAL2), which interacts with the TGF receptor type I (TGFRI), enhances both the proliferation and EMT of GBM cells through the TGF-β/p-Smad2 signaling pathway.48 The gene discussed is TGFB1; the disease is glioblastoma.