Additionally, polycomb repressive complex 2 (PRC2), an important epigenetic modifier in GBM, regulates the EZH2/miR-490/TGFB-induced factor homeobox 2 (TGIF2) axis to activate TGF-β signaling, thus promoting cell migration and EMT.47 The gene discussed is TGFB1; the disease is glioblastoma.