Other research teams have found that the GPER/hypoxia-inducible factor-1 alpha (HIF-1α, a key tumor EMR factor) axis acts as a principal regulator of peri-tumoral stromal remodeling in the fibrovascular tumor microenvironment,198 and GPER-mediated stabilization of HIF-1α contributes to the up-regulation of aerobic glycolysis in tamoxifen-resistant cells.199. Here, GPER1 is linked to neoplasm.