MYB's role in cancer biology is context-dependent: It drives proliferation in malignancies like colorectal cancer and embryonal rhabdomyosarcoma [39, 40], yet paradoxically enhances antitumor immunity in immunogenic tumors (e.g., colon carcinoma) by activating cytotoxic T cells [41]. This evidence concerns the gene MYB and embryonal rhabdomyosarcoma.