CD47 knockout mice showed decreased hepatic cell death and attenuated microglial activation, resulting in significantly improved neurologic scoring and delaying the time to enter hepatic coma after azoxymethane (AOM) treatment as a means of inducing Type A HE, indicating a potential direct or indirect role of CD47 in driving neuroinflammation during HE in acute cases [30]. The gene discussed is CD47; the disease is hereditary elliptocytosis.