Enhanced TNFR1 activation also enhances activation of the TNFR1‐sphingosine‐1‐phosphate receptor 2 (S1PR2)‐CCL2‐BDNF‐TrkB pathway, which mediates microglia and astrocytes activation during hyperammonemia [98]. This evidence concerns the gene NTRK2 and Hyperammonemia.