While many of these studies highlight TNF‐α and its capacity as a potential target during neuroinflammation in chronic HE and chronic hyperammonemia, hyperammonemia is still a large factor in acute HE and thus warrants further studies to confirm if TNF‐α also exerts a similar role in relation to GABA‐ergic tone in Type A HE pathology. The gene discussed is TNF; the disease is hereditary elliptocytosis.