Enhanced TNFR1 activation also enhances activation of the TNFR1‐sphingosine‐1‐phosphate receptor 2 (S1PR2)‐CCL2‐BDNF‐TrkB pathway, which mediates microglia and astrocytes activation during hyperammonemia [98]. Here, TNFRSF1A is linked to Hyperammonemia.