This increase in astrocyte population was coupled with downregulated BDNF in the prefrontal cortex and downregulated IFN‐γ and IL‐6 in the hippocampus [49], potentially indicating the process of reactive astrogliosis and its downstream effects on coordinating neuroinflammatory responses during acute HE may be specific to each brain region. Here, IFNG is linked to hereditary elliptocytosis.