These pathways were ranked by their association with T2DM, with the most significant including: AGE-RAGE signalling in diabetic complications, lipid metabolism and atherosclerosis, TNF signalling, PI3K-Akt signalling, prolactin signalling, Toll-like receptor signalling, insulin resistance, FoxO signalling, IL-17 signalling, and Ras signalling. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.