Interestingly, despite the reported negative effect of TNF-α on bone mineral density, meta‐analysis of 15 studies including 5273 participants demonstrated that the mutant model (GA+AA) of TNF-α -308G>A was associated with decreased susceptibility to osteoporosis, and the AA genotype was associated with increased BMD of the lumbar spine (9). This evidence concerns the gene TNF and osteoporosis.