Similarly, in COVID-19, the activation of PFKFB3- a gene that encodes the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 in neutrophils by SARS-CoV-2, worsens the unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space called NETosis and cytokine storms. This evidence concerns the gene PFKFB3 and COVID-19.