Monocytosis, defined by increased monocyte levels, is significant in Chronic Myeloid Leukemia and Chronic Myelomonocytic Leukemia (CML and CMML), with mutations in ASXL1 and NRAS contributing to disease progression [7, 8]. The gene discussed is ASXL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.