WAS and Cyclic neutropenia: Similarly, CSF3R mutations (e.g., c.359G>A, p.G120D) compromise G-CSF receptor signaling, contributing to cyclic neutropenia, and the Wiskott-Aldrich syndrome protein mutations- *WASP-I292T* gain-of-function mutation demonstrates a distinct mechanism in X-linked neutropenia, supported by murine models [31, 32].