Synergistic effects: ↓ Body weight and adiposity index; ↓ TG, TC, LDL-c; ↑ HDL-c; ↓ lipogenic genes (ACC, Srebp1c, Scd1); ↑ lipolysis genes (Pgc1α, Pparα, CPT1); SIRT1, ↑ p-AMPK, PGC-1α in liver; ↑ PPAR-γ & GLUT-4 in skeletal muscle; ↑ GSH, SOD, T-AOC; ↓ ROS, MDA — all contributing to reduced hepatic steatosis and oxidative stress. The gene discussed is SIRT1; the disease is Hepatic steatosis.