This meta-analysis of 12 randomized controlled trials (RCTs) comprising 731 participants demonstrates that propolis supplementation significantly improves lipid profiles [low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C)], glycemic control [fasting blood sugar (FBS), insulin resistance (HOMA-IR), hemoglobin (HbA1c)], and inflammation [C-reactive protein (CRP)] in patients with T2DM. The gene discussed is CRP; the disease is type 2 diabetes mellitus.