Acute kidney injury: Four studies (Ghali et al. (2025), Khalid et al. (2025), Ng et al. (2025), Tummala et al. (2025)) [20,21,24,26] with 10,724 participants demonstrated an increased incidence of acute kidney injury compared to the GLP-1 group (RR = 1.30, 95% CI = 1.03-1.65, p = 0.03). The gene discussed is GCG; the disease is acute kidney injury.