BDNF and attention deficit-hyperactivity disorder: Furthermore, the study did not find any significant effects of EPA treatment on plasma hs-CRP and BDNF levels, which were measured due to the previous supporting evidence of the role of inflammation and neurotrophin factors in the pathophysiology of ADHD, indicating the need for future studies, which would investigate additional biomarkers involved in the effects of omega-3 treatment in ADHD [14].