UTI: urinary infection; MI: myocardial infarction; T2DM: type 2 diabetes mellitus; T1DM: type 1 diabetes mellitus; DKA: diabetic ketoacidosis; HHS: hyperosmolar hyperglycemic state; SGLT-2i: sodium-glucose cotransporter-2 inhibitors. The gene discussed is SLC5A2; the disease is bacterial urinary tract infection.