Autosomal dominant variants in the NF1 gene, located on chromosome 17q11.2, lead to diverse clinical manifestations, including café-au-lait macules, cutaneous neurofibromas, Lisch nodules, optic gliomas, seizures, pheochromocytomas, and osseous lesions [1]. The gene discussed is NF1; the disease is Cafe-au-lait spot.