CB1, a 59-year-old male with optic nerve hypoplasia, demonstrated the highest NTI (14.8) with extremely short temporal delays (<800 ms), suggesting a specialized architecture optimized for bilateral frontal comparison and rapid parietal integration; this was supported by highly consistent phase stability (PLV = 0.91 for AF3-AF4). Here, AFF1 is linked to Autosomal dominant optic atrophy, classic type.