Other genes that have been identified as key genetic hubs include MAD1L1 and ARNTL [43].Figure 2 shows a pie chart of the most prevalent evidence-based pathophysiologic mechanisms of CVD in BD patients based on the number of papers found in this systematic narrative review of recent literature: cardiovascular dysregulation with eight articles, endothelial dysfunction with five articles, inflammation with eight articles, oxidative stress and metabolic dysregulation with three, and genetics with seven articles. This evidence concerns the gene MAD1L1 and Behcet disease.