BMAL1 and Behcet disease: Other genes that have been identified as key genetic hubs include MAD1L1 and ARNTL [43].Figure 2 shows a pie chart of the most prevalent evidence-based pathophysiologic mechanisms of CVD in BD patients based on the number of papers found in this systematic narrative review of recent literature: cardiovascular dysregulation with eight articles, endothelial dysfunction with five articles, inflammation with eight articles, oxidative stress and metabolic dysregulation with three, and genetics with seven articles.