GLP-1 RA: Glucagon-like peptide-1 receptor agonist; RCT: Randomized controlled trial; CVOT: Cardiovascular outcome trial; T2DM: Type 2 diabetes mellitus; CV: Cardiovascular; DR: Diabetic retinopathy; HR: Hazard ratio; CI: Confidence interval; HbA1c: Hemoglobin A1c; QW: Once weekly; eGFR: Estimated glomerular filtration rate; RRT: Renal replacement therapy; EQW: Exenatide once weekly; LSMD: Least squares mean difference; BMI: Body mass index. Here, GLP1R is linked to type 2 diabetes mellitus.