TP63 and exstrophy-epispadias complex: Variability in expression is well documented in TP63 syndromes, as not every patient exhibits all the classic triad features of EEC, and additional anomalies may be present in some cases but absent in others [8] For instance, an individual with a TP63 mutation might have limb malformations and dental anomalies without a cleft palate, whereas a relative with the same mutation could have the full triad.