TP63 and Ankyloblepharon - ectodermal defects - cleft lip/palate: Generally, the EEC syndrome is caused by mutations in the DNA-binding domain (amino acids ~150-350) of p63 that reduce its transactivation capability, whereas AEC (Hay-Wells) syndrome often results from mutations in the SAM (sterile alpha motif) or TI (transactivation-inhibitory) domains of the protein [5,7].