Median NT-proBNP: 96.0 (38.8-213.0) pg/mL. HS prevalence: 28.6% "HS likely," 43.2% "HS not likely" (grey zone), 28.2% "very unlikely HS." HF risk: 16.7% had NT-proBNP compatible with HF likely. Independent risk factors for HS: CKD (OR = 2.8, 95% CI 1.3-6.2, p = 0.012) and number of antihypertensive drugs (OR = 1.8, 95% CI 1.3-2.5, p = 0.001). The gene discussed is NPPB; the disease is chronic kidney disease.