Search terms included "NT-proBNP", "N-terminal pro-B-type natriuretic peptide", "brain natriuretic peptide", "natriuretic peptide", "type 2 diabetes", "diabetes mellitus", "T2DM", "cardiovascular outcomes", "cardiovascular events", "heart failure", "myocardial infarction", "stroke", "cardiovascular mortality", "risk prediction", "prognosis", and "biomarker". This evidence concerns the gene NPPB and type 2 diabetes mellitus.