NT-pro-BNP is clinically significant in T2DM with preserved ejection fraction > 60% for detecting left ventricular diastolic dysfunction; combined NT-pro-BNP screening and 2D echocardiogram represents the best predictor of diastolic dysfunction and hospitalization due to MACE in T2DM patients. The gene discussed is NPPB; the disease is Left ventricular diastolic dysfunction.