The clinical implications are further illuminated by the cross-sectional study of Landolfo et al., which revealed that 28.6% of asymptomatic T2DM patients with hypertension had evidence of "heart stress" based on age-adjusted NT-proBNP cut points, with an additional 16.7% demonstrating levels compatible with likely HF [10]. The gene discussed is NPPB; the disease is type 2 diabetes mellitus.