PPARGC1A and obesity due to melanocortin 4 receptor deficiency: For PGC1α protein, the interaction effect of obesity and exercise was marginally nonsignificant [F(1,12) = 4.592; partial η2 = 0.277; P = 0.053], whereas significant main effects were observed for obesity [F(1,12) = 16.591; partial η2 = 0.580; P = 0.002] and exercise [F(1,12) = 9.762; partial η2 = 0.449; P = 0.009].