In the hippocampus, for the SIRT1 protein, the interaction effect of obesity and exercise was not significant [F(1,12) = 0.477; partial η2 = 0.038; P = 0.503], whereas main effects of obesity [F(1,12) = 7.277; partial η2 = 0.377; P = 0.019] and exercise [F(1,12) = 7.750; partial η2 = 0.392; P = 0.017] were significant. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.