PPARGC1A and obesity due to melanocortin 4 receptor deficiency: For PGC1α protein, the interaction effect of obesity and exercise was nonsignificant [F(1,16) = 0.153; partial η2 = 0.009; P = 0.701], whereas significant main effects were observed for obesity [F(1,16) = 24.756; partial η2 = 0.607; P < 0.001] and exercise [F(1,16) = 5.063; partial η2 = 0.240; P = 0.039].