SIRT1 and obesity due to melanocortin 4 receptor deficiency: In the prefrontal cortex tissue, for SIRT1 protein, no significant interaction effect of obesity and exercise was detected [F(1,16) = 0.001; partial η2 = 0.000; P = 0.973], but significant main effects were found for obesity [F(1,16) = 35.714; partial η2 = 0.691; P < 0.001] and exercise [F(1,16) = 5.648; partial η2 = 0.261; P = 0.030].