GFAP and Alzheimer disease: To this end, we aimed to investigate if plasma biomarkers of AD (pTau-217, pTau-181, Aβ42/40), neurodegeneration (NfL), and neuroinflammation (GFAP) were associated cross-sectionally with cognitive performance, cortical thickness (as a proxy of early structural neurodegenerative processes),11,12 and their CSF counterparts in a dementia-free, community-based cohort.