NLRP3 and extraskeletal myxoid chondrosarcoma: Knocking out NLRP3 in macrophages shifted their polarization to a proinflammatory M2-like phenotype and significantly reduced ROS production. NLRP3 depletion in M2-polarized macrophages increased the growth, invasion, and metastasis of co-cultured EMC cells. NLRP3 depletion in M1-polarized macrophages reduced phagocytic potential, resulting in weakened immune defense against EMC./These results underscore the critical role of NLRP3 in regulating macrophage polarization, oxidative stress, and immune defense mechanisms against EMC.