Further subgroup analysis revealed that in ACPA-positive RA patients, the CT genotype and dominant model (CT+TT) of this locus were significantly associated with disease risk [(p = 0.040, OR = 6.504, 95% CI: 1.087–38.935) and (p = 0.025, OR = 6.556, 95% CI: 1.272–33.799)]; in RF-positive patients, the TT genotype and codominant model also showed significant associations [(p = 0.044, OR = 2.171, 95% CI: 1.020–4.623) and (p = 0.026, OR = 2.059, 95% CI: 1.089–3.891)]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.