IL6 and serum lipopolysaccharide activity: Recently, in an endotoxemia model, IL-6 plasma clearance significantly decreased over time, decreasing from 25 mL/min (approx. equivalent to 20% extraction ratio at 250 mL/min blood flow) to 10–15 mL/min (approximately 9% extraction ratio) after 5–6 h of treatment with CytoSorb (2).