GO enrichment analysis (Figure 3A) revealed that several BP entries are directly implicated in stroke-related mechanisms, including positive regulation of PI3K/AKT signal transduction, positive regulation of ERK1/2 cascade, response to lipopolysaccharide, positive regulation of cytosolic calcium ion concentration, and positive regulation of angiogenesis, reflecting neuronal survival, neuroinflammation, calcium homeostasis, and post-stroke angiogenesis. The gene discussed is AKT1; the disease is Stroke.