Remarkably, 11 of the 22 tamoxifen-treated Mntfl/flCreERT2/MLL::AF9 AML recipients (2/4 transplanted with 2205, 2/3 with 2206, 4/4 with 2235, and 3/3 with 2233) seemed to be cured (supplemental Table 3). The gene discussed is KMT2A; the disease is acute myeloid leukemia.