NPM1 and acute myeloid leukemia: To extend our studies to human AML, we investigated 4 patient-derived human AML CLs, 3 of which had MLL fusion genes (MV4;11; MLL::AF4,35 MOLM-13; MLL::AF9,37 and THP-1; MLL::AF9),36 and the fourth (OCI-AML3) had NPM1 and DNMT3A mutations.38