Western blot analysis of QVD-OPH–treated Mntfl/flCreERT2/MLL::AF9 AML cells derived from mouse 2235 (Figure 2E) suggested that the increased efficacy of BH3 mimetic drugs after Mnt deletion was because of a further elevation of the BH3-only protein BIM (Bcl-2 Interacting Mediator of cell death), a proapoptotic member of the BCL-2 family.48 This evidence concerns the gene KMT2A and acute myeloid leukemia.