Although treatment with S63845 alone (compare solid black and broken gray curves) prolonged the survival of some T1 MLL::AF9 AML-transplanted mice (outcome for 2205/3413, 2232/3384; Figure 4C-D), it had no impact on others (T1 2201/3378 and T1 2206/3427; Figure 4B,E). The gene discussed is KMT2A; the disease is acute myeloid leukemia.