Other regulators, such as YAP/TAZ-dependent transcriptional programs, hypoxia-response elements like HIF-1α–METTL14, and many non-coding RNAs (circRNAs and LncRNAs) that regulate GPX4 or SLC7A11, also influence ferroptotic sensitivity, unveiling the multilayered ferroptosis regulation complexity in HCC [235], [236], [237], [238], [239], [240], [241]. This evidence concerns the gene GPX4 and hepatocellular carcinoma.