SATB2 and neurodevelopmental disorder: Comparing photographs of 148 individuals with different types of etiological SATB2 variants (Figure S6A) with age-, sex-, and ethnicity-matched controls with neurodevelopmental disorders, we found that individuals with SATB2 variants have a significantly distinctive facial phenotype compared to the background of neurodevelopmental controls (area under the curve [AUC] = 0.91, p = 1.35 × 10−6).