Similarly, in a hyperlipidemia‐induced model of HF with preserved ejection fraction (HFpEF), scRNA‐seq revealed that Timd4 macrophage subpopulations highly express anti‐inflammatory molecules (Figure 2A), while CCR2 macrophages upregulated pro‐inflammatory genes, such as TGF‐β and BMP6, Fos, Myc, Irf1, and TNF‐α, IL‐15, and IL‐6. The gene discussed is CCR2; the disease is hydrops fetalis.