CGAS and infection: In iPSC astrocytes, IFN-β dramatically increased after infection with SARS-CoV-2 (one-way ANOVA followed by Tukey’s method F (2, 6) = 5.495, P = 0.0440, V- vs. V + , P = 0.0475) and was blocked by the cGAS inhibitor G140 indicating a possible contribution of this pathway to the antiviral response (Fig. 2 A).