Among asymptomatic individuals with a diagnosis of MSH2-Lynch syndrome (excluding case A), urine MSI analysis detected asymptomatic urothelial carcinoma with 100% sensitivity (95% CI 39.8–100.0%), 98.7% specificity (95% CI 92.9–99.9%), 80% PPV (95% CI 28.4%-99.5%), and 100% NPV (95% CI 95.2–100.0%) (Supplementary Table S6). The gene discussed is MSH2; the disease is urothelial carcinoma.