MSH2 and urothelial carcinoma: In a regional pilot study aiming to demonstrate the feasibility of using the assay as a Lynch syndrome urothelial carcinoma screening test, we screened urine samples from asymptomatic individuals with a diagnosis of MSH2-Lynch syndrome and unselected cases of UTUC to calculate initial estimates of the sensitivity and specificity of the assay for MMRd urothelial carcinoma detection.