In light of our in vivo results and because the inflammatory response of MDMs from patients with SPG11 was strongly increased in response to the activation of the non-canonical inflammasome, it is tempting to speculate that patients with SPG11 might be more susceptible for organ dysfunction upon infection with Gram-negative bacteria, in particular sepsis-associated encephalopathy, a frequent complication of sepsis presenting with delirium, coma, and increased mortality.69 Here, SPG11 is linked to infection.