SLC22A11 and hyperuricemia: SLC22A11 and SLC22A12 encode renal uric acid transporter proteins (URATs) located on chromosome 11.[24] According to GWASs, SNP rs17300741 of the SLC22A11 gene was strongly associated with SUA levels.[25] Multiple SNPs of SLC22A12 were significantly associated with hyperuricemia and gout.[26] In Han Chinese men, the SLC22A12 rs559946 polymorphism was associated with hyperuricemia risk, and the major C allele with increased gout risk.[27]