For HL cohorts, GSE49543 revealed 5 upregulated genes (AIMP2, SEMA5A, GUSB, C1QA, GYPC) and 4 downregulated genes (RASL12, IRF7, C1QB, SERPING1) compared to controls (P < .05; Fig. 7E). Here, SEMA5A is linked to Hodgkins lymphoma.