The results showed that in terms of clinicopathological features, B7x was closely related to lymph node status (odds ratio [OR] = 2.80, 95% confidence interval [CI] = 1.54–5.11, P = .001), tumor differentiation (OR = 2.95, 95% CI = 1.91–4.57, P < .001), and FIGO stage (OR = 3.88, 95% CI = 3.04–4.94, P < .001) of female reproductive system malignant tumor patients. The gene discussed is VTCN1; the disease is cancer.