Xing et al[29] demonstrated that BUR1, a novel piperidine, can significantly reduce pulmonary artery pressure and right ventricular systolic pressure, thereby preventing right ventricular hypertrophy and peripheral pulmonary artery thickening primarily by inducing the expression of bone morphogenetic protein 2 (BMP2) and PTGS2 in the SU/Hy rat model. The gene discussed is PTGS2; the disease is Right ventricular hypertrophy.