VEGFA and pulmonary arterial hypertension: The decreased VEGFA expression may have aggravated pulmonary vascular remodeling and increased the degree of tissue hypoxia, which is consistent with our findings.[5] In addition, Campbell et al[11] demonstrated that cell-based VEGFA gene transfer is a practical method for preventing and delaying the progression of pulmonary hypertension in a monocrotaline model; thus, targeting VEGFA demonstrates therapeutic potential for pulmonary hypertension intervention.