GFER and hyperandrogenism: PCOS, a disease closely related to HPO axis dysregulation, is characterized by follicular dysplasia, hyperandrogenism, and metabolic abnormalities.[50,51] Previous studies have demonstrated that EA effectively regulates hormonal fluctuations of the HPO axis in rats by stimulating the Sanyinjiao (SP6) and Zusanli (ST36) acupuncture points.