INS and type 2 diabetes mellitus: On the other hand, chronic stimulation of insulin secretion may exhaust β-cells.[42] Banerjee and Saxena reported that IL-1β, a proinflammatory factor, inhibits β-cell function and promotes β-cell apoptosis.[43] Vesa et al reported that dropping insulin secretion in newly diagnosed T2DM patients may be due to the elevation of IL-1β level, which affects beta cell function.[44]