IL1B and type 2 diabetes mellitus: This SNP is located in the promoter region of the IL-1β gene, specifically at position -511 of the gene’s transcription start site.[16] The IL-1β (rs16944) variant has been investigated in relation to T2DM; IL-1β is a proinflammatory cytokine, and inflammation plays a role in the pathogenesis of T2DM.[24] The IL-1β gene variant rs16944 is located in the promoter region, and it can affect the production and activity of IL-1β.[25] The activity associated with rs16944 can affect the gene’s expression and, consequently, the levels of IL-1β produced.