INS and cardiovascular disorder: When diagnosing IR, TyG demonstrates a strong connection with the gold standard insulin high-normoglycemic clamp technique (HEC).[24] An investigation conducted by Rafiee H et al[25] uncovered an important link between an increased TyG index and an elevated danger of stroke (HR = 1.45; 95% CI: 0.96–2.19; P = .042, threshold: 8.92) and cardiovascular disease (HR = 1.48; 95% CI 1.22–1.79; P < .001, threshold: 8.91).