INS and cancer: It has been demonstrated that several ARBs increase oxidative stress, which promotes carcinogenesis.[27] They may also lessen the body’s capacity to stop aberrant cell growth by interfering with tumor suppressor pathways, such as the p53 pathway.[28] ARBs can also alter glucose metabolism and insulin sensitivity; disruption of these metabolic pathways is linked to a higher risk of cancer.[29] Also, the elevated catecholamine levels in hypertensive patients are indicative of a major role played by sympathoadrenal activity in the development of HTN.