Studies have shown that there is a strong genetic component in the risk of hyperprolactinemia.[6]The genetic mechanism of hyperprolactinemia may not be a simple single gene mutation, but multiple gene changes, such as prolactin receptor mutations and polymorphisms.[7] Gut microbiota may influence the occurrence and progression of diseases by producing certain metabolites and regulating disease-related genes, thereby causing changes in endocrine system signaling pathways.[8]. Here, PRLR is linked to hyperprolactinemia.