It induces insulin resistance by promoting IRS-1 serine phosphorylation (Ser307) to inhibit insulin receptor signaling and downregulating AKT1 phosphorylation at Thr308/Ser473, thereby impairing GLUT4 membrane translocation and skeletal muscle glucose uptake.[20–23] One of the core pathological characteristics of T2DM is the progressive decline in function and reduction in number of pancreatic beta cells. This evidence concerns the gene INSR and Insulin resistance.